| abstract |
PROCEDURE TO PREPARE NEW 3-ALCOXY-2- (N-PYRROLIDIN) -N-PYRIDYL-N-FURYLMETIL-PROPYLAMINES. IT INCLUDES: A) REACTING A COMPOUND OF FORMULA (IV) WITH AMINOPYRIDINE, IN THE PRESENCE OF A METALLIC AGENT -METAL ALKALINE (SODIUM HYDRIDE), TO OBTAIN A COMPOUND OF FORMULA (II); AND B) TREAT (II) WITH AN AMINE OF FORMULA (III), TO OBTAIN NEW 3-ALCOXI-2- (N-PYRROLIDINE) -N-PYRIDYL-N-FURYLMETIL PROPYLAMINES OF FORMULA (I) AND THEIR ADDITION SALTS OF PHARMACEUTICALLY ACCEPTABLE ACID. BEING: R, LINEAR OR BRANCHED RENT FROM C 1 TO 7; HAL, CL OR BR; AND X, O OR S. ARE USED AS ANTIANGINAL ANTI-HYPERTENSIVE AND ANTI-DIARRHYTHMIC AGENTS. |