abstract |
PROCEDURE TO PREPARE PIRIDO (3,4-H) PSORARENES OR PIRIDO (3K,4K; 4,5) FURO (3,2-G) COUMARINS. COMPRISES: A) REACTING AN AMINOOXI-7-COUMARINE OF FORMULA (II) IN WHICH R IS SELECTED FROM THE GROUP CONSISTING OF A HYDROGEN ATOM AND A LOWER ALCOHOL GROUP OF C 1 TO 4, AND RK IS SELECTED FROM THE GROUP CONSISTING OF IN A METHYL GROUP AND A METHOXY GROUP, WITH A 4-PIPERIDONE OF FORMULA (III) IN WHICH Y IS A HYDROGEN ATOM, TO PRODUCE AN OXIME OF FORMULA (IV); B) CYCLING THE OXIME OF FORMULA (IV) IN AN ACID MEDIUM, TO OBTAIN IN IT A TETRAHYDRO-1,2,3,4-PYRIDO (3K,4K; 4.5) PSORALENE OF FORMULA (V); AND C) AROMATIZING THE TETRAHYDRO 1,2,3,4-PYRIDO (3K,4K; 4,5) PSORALENE IN THE PRESENCE OF A DEHYDROGENATION AGENT, TO OBTAIN THE PYRIDO (3,4-H)-PSORALENS OR PYRIDO COMPOUND ( 3K, 4K, 4.5) FURO (3.2-G) COUMARINS OF FORMULA (I). IT IS USED IN THE TREATMENT OF SKIN DISEASES AND FOR THE TREATMENT OF BENIGN AND MALIGNANT INFLAMMATORY DERMATOSES. |