| abstract |
SYNTHESIS OF PHARMACOLOGICAL DERIVATIVES OF 3- (UREIDO-CYCLOHEXYLAMINE) -PROPAN-1,2-DIOL. IT INCLUDES: A) CONDENSING AN ACID OF FORMULA (II) WITH AN AMINE OF FORMULA (III) IN THE PRESENCE OF A REACTING AGENT FOR COPULATION SUCH AS DICICLOHEXYLCARBODIIMIDE, TO OBTAIN A COMPOUND OF FORMULA (IV); AND B) REDUCE THE COMPOUND OF FORMULA (IV) WITH ALKALINE HYDRIDES OR WITH ALANE, BORANE OR LITHIUM-ALUMINUM HYDRIDE TO OBTAIN A COMPOUND OF FORMULA (I), AND IF DESIRED, ITS PHARMACOLOGICALLY COMPATIBLE SALTS. BEING: AR, AROMATIC REST; R, H, ALKANOYL OR AROYL; R1 AND R2, SEPARATELY, H OR LOWER RENT, TOGETHER, RENT FROM C 2 TO 7; R3 AND R4, H OR LOWER ALKYL; AND X, OXO OR UNCLE. THEY ARE USED IN PHARMACOLOGY AS ANTIHypertensive. |