| abstract |
PROCEDURE FOR OBTAINING SPIRO-HYDANTOIN DERIVATIVES AND ITS PHYSIOLOGICALLY COMPATIBLE SALTS, OF FORMULAS (I) OR (II), IN WHICH Z IS HYDROGEN OR AMINO; FA-BFD- REPRESENTS FN-CHFCH, FCH-CHFN- OR FCH-NFCH; AND X, Y, R, RK AND RL CAN BE SEVERAL TYPES OF RADICALS. IT INCLUDES THE ALKYLATION REACTION OF ETHYL SODIUM-HYDANTOIN-5-CARBOXYLATE WITH AN APPROPRIATE HALONITRO-DISUSTITUTED PYRIDINE; FOLLOWED BY REDUCTIVE CYCLING OF THE COMPOUND OBTAINED, BY TREATMENT WITH POWDERED IRON, IN THE PRESENCE OF AN ACID, AT A TEMPERATURE OF BETWEEN 20J AND 100JC. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THE TREATMENT OF DIABETIC CATARACTS, RETINOPATHIES AND NEUROPATHIES. |