abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF QUINAZOLINE AND ITS PHYSIOLOGICALLY COMPATIBLE ACID ADDITION SALTS, OF FORMULA (I), IN WHICH D AND D IS NITROGEN AND THE OTHER IS CARBON; R3 IS C2-7 ALKYLENE; R4 IS C1-7 ALKYLENE; Y IS OXYGEN OR SULFUR; R1, R2, A AND X MAY BE MULTIPLE RADICALS; AND M AND N ARE VALUE 0 OR 1. INCLUDES THE REACTION OF A CARBOXYLIC ACID OF FORMULA (II) WITH A COMPOUND OF FORMULA -R3-(Y)M-(R4)N-A, IN WHICH Z IS A LEAVING GROUP AND THE OTHER SYMBOLS HAVE THE SAME MEANING AS IN FORMULA (I). THE REACTION IS CARRIED OUT IN AN APROTIC POLAR SOLVENT, AT A TEMPERATURE BETWEEN 0JC AND THE REFLUX TEMPERATURE OF THE REACTION MIXTURE. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THE TREATMENT OF ALLERGIC CONDITIONS AND VASCULAR DISORDERS INVOLVING THROMBOSIS. |