abstract |
PROCEDURE TO PREPARE 9-ANTRYLOXAMINOALKANES. IT CONSISTS OF HYDROLYZING A COMPOUND OF FORMULA (II) WITH 1 TO 5 MOLAR EQUIVALENTS OF AN INORGANIC BASE SUCH AS SODIUM OR POTASSIUM HYDROXIDE, IN A SOLVENT WITH METHANOL, ETHANOL AND 10 TO 90% WATER, AT A TEMPERATURE BETWEEN 25JC AND THE TEMPERATURE OF REFLUX AND FOR 1 TO 24 HOURS, TO OBTAIN A COMPOUND OF FORMULA (I) AND ITS SALTS OF ADDITION OF PHARMACEUTICALLY ACCEPTABLE ACIDS. BEING: Y AND Z HALO (FLUORINE, CHLORINE, BROMINE), ALKYL FROM C 1 TO 8 AND OTHERS; X. -NR1R2 / R1 Y R2, H; R4 -COR5; R5, ALKYL, ARILO AND OTHERS; B A NUMBER FROM 2 TO 12; AND L AND M INTEGRAL NUMBERS FROM 0 TO 4. ARE USED TO TREAT INFLAMMATION, PAIN AND SWELLING. |