http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-8606407-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 |
filingDate | 1984-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 1986-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-8606407-A1 |
titleOfInvention | A PROCEDURE FOR PREPARING GALACTOSIL-INSULIN CONJUGATES |
abstract | PROCEDURE FOR PREPARING GALACTOSIL-INSULIN CONJUGATES. IT INCLUDES: A) DISSOLVING LACTOBIONIC ACID OR MELIBIONIC ACID AND N, NK-DICYCLOHEXYLCARBODIIMIDE IN AN APROTICAL SOLVENT SUCH AS PYRIDINE, AT A TEMPERATURE OF 0JC FOR 0.5 HOURS; B) ADD N-HYDROXYSUCCINIMIDE TO THE APROTICO SOLVENT; C) AFTER THE OPERATION (B), SHAKE THE SOLVENT AT 3JC FOR 20 HOURS TO FORM THE N-HYDROXYSUCCINIMIDE ESTER LACTOBIONATE OR MELIOBIONATE; D) DISSOLVE N-HYDROXYSUCCINIMIDE ESTER LACTOBIONATE OR MELIBIONATE IN WATER TO FORM AN AQUEOUS SOLUTION OF THE SAME; E) ADD THE AQUEOUS SOLUTION DROP BY DROP DURING A PERIOD OF 30 MINUTES TO A SALT SOLUTION CONTAINING INSULIN MAINTAINED AT A PH OF 7 OR 8.5, AND AT ROOM TEMPERTURE; AND F) SEPARATE THE LACTOBIONIL-INSULIN OR MELIBIONOL-INSULIN CONJUGATES FROM THE SALINE SOLUTION. |
priorityDate | 1983-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.