abstract |
PROCEDURE FOR THE PREPARATION OF BENZOTRIAZOLE AND BENZOXAZOLAMINE DERIVATIVES, OF THEIR ACID ADDITION SALTS AND THEIR POSSIBLE STEROISOMERS, OF FORMULA (I); WHERE: -A1FA2-A3FA4- IS A DIVALENT RADICAL IN WHICH ONE OR TWO ATOMS OF HYDROGEN CAN INDEPENDENTLY BE REPLACED BY HALOGEN, ALKYL OR ALKYLOXY OF 1 TO 6 ATOMS OF C, HYDROXY OR TRIFLUOROME; Z IS O O S; N IS O O 1; R MAY REPRESENT HYDROGEN, ALKYL OR ALKYLOXY FROM 1 TO 6 C OR HYDROXY ATOMS; R1 OR R2 IS HYDROGEN, AN ALKYL OR ARYLALKYL RADICAL OF 1 TO 6 C ATOMS; R3 AND R4 ARE BOTH HYDROGEN OR THEY CONSTITUTE TOGETHER THE DIVALENT RADICAL -CH2-CH2-; AND L IS A LINEAR OR CYCLIC RADICAL FROM AMONG A SELECTED SPECIFIC GROUP. CONSISTENT OF SUBMITTING A PIPERIDINE OF FORMULA (II) TO N-ALKYLATION BY MEANS OF A SPECIFIC REAGENT AND IN THE PRESENCE OF AN AROMATIC HYDROCARBON AS A SOLVENT. OF APPLICATION IN PHARMACOLOGY FOR ITS ANTIHIPOXIC AND ANTIANOXIC PROPERTIES. |