| abstract |
PROCEDURE FOR THE PREPARATION OF NEW SPIRO-E-HETEROAZOLIDINDIONAS. IT CONSISTS OF HYDROLIZING A COMPOUND OF FORMULA (II) WITH A MINERAL ACID SUCH AS TOLUENSULPHONIC, HYDROCHLORIC, HYDROBROMIC, IN TOLUENE OR 3-METHYL-2-BUTANOL, BETWEEN 80J AND 150JC, IN ORDER TO OBTAIN NEW SPIRO-HOLE-3 FORMULINDE ) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS. BEING: X H OR ALKYL C 1 TO 4; Y Y Z, H, HAL, NITRO, TRIFLUORMETHYL AND OTHERS; O O S AND OTHERS AND N 0 O 1. THEY ARE USED AS INHIBITORS OF ALDOSA REDUCING ENZYME IN THE TREATMENT OF CHRONIC COMPLICATIONS OF DIABETES SUCH AS DIABETIC CATARACTS, RETINOPATHY AND NEUROPATHY. |