| abstract |
METHOD FOR THE PREPARATION OF A COMPOUND OF 3-INDOLCARBOXAMIDE. CONSISTS OF REACTING A COMPOUND OF FORMUAL (II) OR A FUNCTIONAL DERIVATIVE OF THE SAME, WITH A COMPOUND OF FORMULA (III), IN AN INERT SOLVENT, IN THE PRESENCE OF A CONDENSING AGENT, SUCH AS TITANIUM TETRACHLORIDE, CARBIOIIMIDE, OR A HALLOWEEN HAL PHOSPHORUS, TO OBTAIN A COMPOUND OF FORMULA (I). BEING: R1, H, OR ALKYL FROM C1 TO 4; R2 AND R3, EACH, H, HAL, ALCOXI AND THE OTHERS; R4, AS R1; R5, H, HAL, HYDROXYL GROUP, AND OTHERS; R6, AS R1; X, OXYGEN ATOM, SULFUR, OR A DIRECT LINK; K AND M, 1, 2 OR 3, INDEPENDENTLY; AND N, 1 OR 2. ARE USED IN PHARMACOLOGY FOR THE PREVENTION AND TREATMENT OF CIRCULATORY DISEASES. |