abstract |
PROCEDURE TO PREPARE NEW DERIVATIVES OF AMINOTETHRALINE. IT CONSISTS OF REACTING A COMPOUND OF FORMULA (II) WITH A COMPOUND OF FORMULA (III), IN ACETONE OR DIETHYLETER, IN THE PRESENCE OF THIRD-BUTYLATE POTASSIUM OR SODIUM HYDROXIDE AND POTASSIUM IODIDE AND AT A TEMPERATURE BETWEEN 150J AND BETWEEN 150J A COMPOUND OF FORMULA (I) AND ITS ACID ADDITION SALTS. BEING: A, -CH2-CH2, CHFCH- AND OTHERS; B, METHYLENE, CARBONYL AND OTHERS; R1, R3 AND R4, H, HAL, NITRO AND OTHERS; R2, H, CL OR BR, ALCOXY AND OTHERS; R5, H, AN ALKENYL FROM C 3 TO 5 AND OTHERS; R1, R3 AND R4, PROTECTED HYDROXY, AMINE OR ALKYLAMINE; R2, HYDROXY PROTECTED BY A RADICAL PROTECTOR; R5, A PROTECTIVE GROUP FOR AN AMINO GROUP; AND U A NUCLEOPHILIAN LABOR GROUP SUCH AS HAL OR A SULFONYLOXI GROUP. IT IS USED TO REDUCE THE EFFECT OF THE HEART RATE AND THE O2 CONSUMPTION OF THE HEART. |