abstract |
PROCEDURE FOR OBTAINING TIADIAZOLE DERIVATIVES AND ITS PHYSIOLOGICALLY COMPATIBLE SALTS, OF FORMULA (I), IN WHICH R MAY BE ONE OF SEVERAL TYPES OF RADICALS; COMPOUNDS THAT HAVE PHARMACOLOGICAL APPLICATIONS DUE TO THEIR ACTIVITY ON THE CENTRAL NERVOUS SYSTEM. + C + N UNDERSTANDS THE REACTION OF A HALOGEN-2-THADIAZOL-1,3,4 OF FORMULA (II), IN WHICH X REPRESENTS CHLORINE OR BROMINE AND R IS THE SAME AS IN FORMULA (I), WITH AN AMINE OF FORMULA (III) IN EXCESS WITH REGARD TO THE 1: 1 MOLAR RATIO. THE REACTION IS CARRIED OUT IN AN INERT ORGANIC SOLVENT, SUCH AS BUTANOL-1, IN THE PRESENCE OF POTASSIUM IODIDE, AT THE REFLUX TEMPERATURE OF THE REACTION MIXTURE. |