abstract |
PROCEDURE FOR PREPARING DERIVATIVES OF 4,5,6,7-TETRAHIDROFURO -O 1H-PIRROLO-2,3, CPIRIDINA. IT INCLUDES: A) CYCLING A COMPOUND OF FORMULA (II), IN THE PRESENCE OF ALKALINE HYDRIDE, TO OBTAIN A COMPOUND OF FORMULA (III); B) TO REACT (III) WITH AN ACETOPHENONE OF FORMULA (IV), TO MAKE A COMPOUND OF FORMULA (IV); C) CYCLING (V), IN THE PRESENCE OF AMMONIUM ACETATE AND ACETIC ACID, TO OBTAIN A COMPOUND OF FORMULA (VI); AND D) TREAT (VI) WITH NAOH AND THEN WITH CLH, TO OBTAIN A COMPOUND OF FORMULA (I). BEING: X, O O NH; R1, PHENYL WITH TWO HALS, METHYL OR ETHYL; AND R2, H O BENZOYL. THEY ARE USED FOR THE TREATMENT OF ALTERATIONS IMPUTABLE TO BRAIN VASCULAR DAMAGE AND BRAIN SCLEROSIS. |