abstract |
PROCEDURE FOR OBTAINING HALOGENATED QUINOLONE CARBOXYL ACIDS. IT INCLUDES: A) CYCLOCONDENSING THE 2-BENZOYL-3-AMINOCRYLONITRILE OF FORMULA (III) WITH POTASSIUM CARBONATE, IN DIMETHYLFORMAMIDE AND AT A TEMPERATURE OF 150JC, TO OBTAIN THE NITRILS OF QUINOLONCARBOXYL ACID (II); B) SAPONIFYING THE QUINOLONCARBOXYL ACID NITRILES OF FORMULA (II), IN ALKALINE OR ACID MEDIA, TO OBTAIN A COMPOUND OF FORMULA (I). BEING: R ALKYL FROM C 1 TO 3, 2-FLUORETILO, PHENYL AND OTHERS; X HALOGEN, CHLORINE OR BROMINE; X1 AND X2 HYDROGEN OR HALOGEN; AND X3 HALOGEN, CHLORINE OR FLUORINE. THEY ARE USED AS INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF ANTIBACTERIAAL DRUGS. |