| abstract |
METHOD OF PREPARING PHOSPHORUS COMPOUNDS. IT INCLUDES: A) REACTING A COMPOUND OF FORMULA (I), R3 HO BEING AN ALKALINE METAL SALT AND R6 BENZYL OR BENZHYDRILE WITH A COMPOUND OF FORMULA (II) IN THE PRESENCE OF A BASE SUCH AS AMMONIUM SALTS, BENZATINE SALTS, AND OTHERS ; AND B) HYDROGENATE THE COMPOUND OBTAINED IN A) TO OBTAIN A COMPOUND OF FORMULA (I) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS. BEING R1 AND R2, H, LOWER ALCOHYL, LOWER ALCOHYL REPLACED BY HALOGEN AND OTHERS; X AN IMINO OR AMINO ACID OF FORMULA (III) AND OTHERS; TO A GROUP OF FORMULA (IV); R3 A GROUP OF FORMULA (V); R6, R7 H, HAL AND OTHERS; R17, R18 AND R21 H, LOWER ALCOHYL AND OTHERS AND N 0 O 1. ARE USED AS ANTIHYPERTENSIVE. |