abstract |
PROCEDURE FOR THE PREPARATION OF N-PYRIDYLINDOLES. CONSISTENT OF: A) REACTING A STRONG BASE SUCH AS BUTYL-LITHIUM AT A TEMPERATURE BETWEEN C70 AND 50JC WITH A COMPOUND OF FORMULA (IA); B) CONDENSING THE PRODUCT FROM A) WITH CARBON DIOXIDE OR A LOWER ALKYL HALOFORMATE; AND C) HYDROLIZE THE PRODUCT FROM B) TO OBTAIN (I). BEING: AR F 3- O 4-PYRIDYL AND OTHERS; THE R1 INDEPENDENTLY ONE OF THE OTHER, H, HALOGEN, TRIFLUORMETHYL AND OTHERS; ONE OF R3 AND R4 REPRESENTS H AND THE OTHER A GROUP A-B IN WHICH A CONTAINS A TRIPLE LINK ADJACENT TO GROUP CARBOXI AND B IS CARBOXI; AND R3 AND R4 INDEPENDENTLY ONE IS H AND THE OTHER REPRESENTS GROUP A-C IN WHICH C IS A DIFFERENT GROUP FROM B AND TRANSFORMABLE IN B. IT IS USED IN THE TREATMENT OF DISEASES SENSITIVE TO THE INHIBITION OF TROMYPHEROSANE SYNTHETASE IN MAMMIFBOXANE. |