| abstract |
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-AMINO-4,5-DIHIDRO-2-THIOFENCARBOXILICO ACID. IT CONSISTS OF SUBMITTING THE CORRESPONDING 3-AMINO-4,5-DIHYDRO-2-THIOFENCARBOXYL ACID N-PROTECTED TO A DEPROTECTION REACTION TO OBTAIN DERIVATIVES OF THE 4-AMINO-4,5-DIHYDRO-2-THIOFENCARBOXYL ACID (I) OF FORMONULDEA R IS HO ALKYL FROM C 1 TO 6 AND ITS INDIVIDUAL SALTS AND ENANTIOMERS AND RACEMIC MIXTURES, AND OPTIONALLY, STERIFY THE COMPOUND OBTAINED FROM FORMULA (I) AND / OR FORM A SALT OF THE SAME. THE N-PROTECTOR GROUP IS T-BUTOXICARBONYL AND THE DEPROTECTION IS CARRIED OUT WITH HC1 AT THE TEMPERATURE OF AN ICE BATH. THEY HAVE PHARMACEUTICAL APPLICATIONS WITH ACID-G-AMINOBUTYRICO-TRANSAMINASE INHIBITORS, USEFUL IN THE TREATMENT OF EPILEPSY. |