abstract |
PROCEDURE FOR PREPARING IMIDAZOLE DERIVATIVES. IT CONSISTS OF REACTING A COMPOUND OF FORMULA (II) WITH AN AMOUNT OF A COMPOUND OF FORMULA NH2-R2 SUFFICIENT TO FORM 2-INTERMEDIATE IMINES; AND HYDROGENATE THE INTERMEDIATE 2-IMINES USING AN APPROPRIATE HYDROGENATION AGENT OR HYDROGENATION CATALYST, AT SUFFICIENT PRESSURE AND FOR A SUFFICIENT TIME TO PRODUCE IMIDAZOL DERIVATIVES OF FORMULA (I) WHERE, AND OTHERS-H ; X IS -H, -OH, -F, -CF3 OR C 1 TO 4 ALKYL; R IS -CH2NHR1; R1 IS -H, PHENYL OR BENZYL; AND N IS 0-4 OR A PHARMACEUTICALLY ACCEPTABLE ACID SALT OR HYDRATE OF THE DERIVATIVES. THEY HAVE PHARMACOILOGICAL UTILITY AS INHIBITORS OF DOPAMINE-B-HYDROXYLS |