abstract |
METHOD TO PREPARE AN ASYMMETRIC DIESTER OF THE 1,4-DIHYDRO-2,6-DIMETHYLPYRIDIN-3,5-DICARBOXYL ACID OF FORMULA (I) BEING: PH PHENYL GROUP, AR SUBSTITUTED PHENYL, TO LINEAR CHAIN ALKYLENE 2-6 ATOMS OF CARBON, R ALKYL 1-6 CARBON ATOMS, R1 HYDROGEN, HYDROXY OR ALKYL 1-4 CARBON ATOMS AND R2 HYDROGEN OR METHYL. IT CONDENSES AN AR-CHO COMPOUND WITH A CH3-CO-CH2-COOAX, BEING X A HALOGEN ; THE CONDENSATE IS REACTED WITH A COMPOUND OF FORMULA CH3-NH2-C CHCOOR TO GIVE A PRODUCT OF FORMULA (VI) BEING A1 AX WHICH IS REACTED WITH A DERIVATIVE OF 3-3 DIPHENYLPROPYLAMINE TO GIVE THE PRODUCT (I). APPLICABLE AS ANTIHYPERTENSIVE FOR CORONARY DISORDERS. |