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filingDate 1984-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1985-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-8602407-A1
titleOfInvention IMPROVEMENTS IN THE MANUFACTURING METHODS OF ACID 3-CHLORO-7-D- (2-FENYLGLYCINAMIDE) -3-CEFEM-4-CARBOXYL MONOHYDRATED
abstract MANUFACTURE OF A LONG-TERM FORMULATION OF A CEPHALOSPORAN DERIVATIVE. IT INCLUDES A QUICK RELEASE COMPONENT AND ANOTHER SLOW RELEASE COMPONENT, IN ORDER TO GET A PROLONGED RELEASE, IN A PROPORTION BETWEEN 3: 7 TO 5: 5, IN THE WAY THAT THE SLOW RELEASE COMPONENT IN THE FORM OF PARTICLES COATED WITH A SOLUBLE ENTERIC POLYMER FILM AT A PH BETWEEN 5 AND 7, IT IS SPRAYED WITH THE QUICK RELEASE COMPONENT, SUCH COMPONENTS BEING CEFACLOR (3-CHLORO-7-D) (2-PHENYLGLYCINAMIDE) -3-CEFEM-4-CARBOXYL MONOHYDRATE). THE SLOW RELEASE COMPONENT AND THE QUICK RELEASE COMPONENT ARE PREPARED SEPARATELY AND THEN FILLED INTO A HARD AND SOLUBLE CAPSULE AS A UNIT DOSAGE FORM. BROAD SPECTRUM ANTIBIOTIC.
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