abstract |
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 1-NORMON-2-ILO. A COMPOUND OF FORMULA (II), WHERE R1 IS C1-20 ALKYL, C2-8 ALKENYL, ARYL, ARALKYL, HETEROCYCLE (OPTIONALLY SUBSTITUTED), HYDROGEN OR C3 CYCLOALKYL -7, AND THE SUBSTITUENTS Z1, Z2 AND Z3 ARE THE SAME OR DIFFERENT, EACH BEING HYDROGEN OR A HYDROXYL PROTECTING GROUP, IS REACTED AT LOW TEMPERATURE (20 CA 20 C) WITH PHOSGENE AND A TERTIARY AMINE (PREFERENTLY TRIETHYLAMINE ) AND SUBSEQUENTLY WITH TETRAMETHYLGUANIDINIUM ACID, TO OBTAIN A COMPOUND OF FORMULA (I) WHICH VARY ACCORDING TO THE NATURE OF THE SUBSTITUTE R1 AND ACCORDING TO THE ZOE CONFIGURATION OF THE TRI-SUBSTITUTED DOUBLE BOND. A METHOD FOR OBTAINING OTHER COMPOUNDS OF FORMULA (I) BY SUBSEQUENT MODIFICATIONS OF THE SUBSTITUTE R1 IS ALSO DESCRIBED. THEY ARE USED AS ANTIBACTERIAL AND ANTIMYCOPLASMIC DRUGS. |