abstract |
PROCEDURE TO PREPARE ARYLOXY- AND ARYLTIO-HYDROXYPROPILEN-PIPERAZINYL-ACETANILIDES CARDIOSELECTIVAS THAT AFFECT THE INPUT OF CALCIUM. IT CONSISTS OF REACTING A PIPERAZINE, WHICH CARRIES ONE OF THE BRANCHES OF THE SIDE CHAIN OF FORMULA (I) WITH A SOURCE OF THE OTHER BRANCH OF THE SIDE CHAIN OF THE FORMULA COMPOUND (I) WHERE R1, R2, R3, R4 AND R5 ARE ONE INDEPENDENTLY, H, LOWER ALKYL, LOWER ALCOXY, CYANE, TRIFLUOROMETHYL AND OTHERS; R6, R7, R8, R9 AND R10 ARE EACH INDEPENDENTLY, H, LOWER ACIL, AMINOCARBONYL METHYL, ARYL, CYANE AND OTHERS; R11 AND R12 ARE EACH INDEPENDENTLY H OR LOWER RENT; AND W IS OXYGEN OR SULFUR. THEY HAVE APPLICATIONS IN DISEASES IN HUMAN BEINGS THAT ARE AFFECTED BY A BLOCK IN THE INLET OF CALCIUM. |