| abstract |
PROCEDURE FOR THE PREPARATION OF LEUCINE DERIVATIVES, INCLUDING: A) AEROBICALLY CULTIVATING A MICROORGANISM OF THE SPECIES STREPTOMYCES TOXYTRICINI, IN AN AQUEOUS CULTIVATION MEDIUM CONTAINING SOURCES OF CYN (APPROPRIATE 3 LYN, AND 2 INORGANIC SALTS) , 7Z, 10Z) -S- (S) -2-FORMAMIDO-4-METHYL-VALERIOLOXY -2-HEXYL-3-HYDROXY-7,10-HEXADECADIENOICO OF FORMULA (I). BEING; TO A GROUP OF FORMULA (II) O (CH2) S- AND B) SEPARATE THE COMPOUND OF FORMULA (I) FROM CULTURE BROTH. THE STREPTOMYCES TOXYTRICINI MICROORGANISM, CHOOSE BETWEEN NRRL 15,443 OR A SUBCULTURE. THE APPROPRIATE SOURCES OF CARBON ARE CHOSEN BETWEEN DEXTRIN, GLUCOSE, STARCH OR RIBOSE AND THE APPROPRIATE SOURCES OF NITROGEN ARE CHOSEN BETWEEN WASHING EXTRACT, PEPTON OR SOYBEAN FLOUR AND THE SALTS ARE CHOSEN BETWEEN AMMONIA AND CALCIMS. |