abstract |
PROCEDURE FOR PREPARING SUBSTITUTED BENZENES. INCLUDES: HYDROLYZING, BY ALKALINE HYDROLYSIS, IN AN AQUEOUS OR AQUEOUS ALCOLIC MEDIUM, AT A TEMPERATURE BETWEEN 15JC AND THE REFLUX TEMPERATURE, A COMPOUND OF FORMULA (II) IN WHICH, EITHER, X IS F S AND Z IS -OR5 WHERE R5 IS C 1 TO 4 O X IS F NH AND Z IS -NH2, TO PREPARE A COMPOUND OF FORMULA (I) IN WHICH R3 IS H; AND OPTIONALLY ACYLATE THE COMPOUND OF FORMULA (I) IN WHICH R2 AND/OR R3 IS (N) AN ATOM OF H, IN THE PRESENCE OF AN INERT SOLVENT OR DILUENT, AT A TEMPERATURE BETWEEN 15 AND 50JC; AND/OR SUBJECT TO S-S-DIMERIZATION A COMPOUND OF FORMULA (I) TO WHICH R3 IS H, BY OXIDATION, IN THE PRESENCE OF ATMOSPHERIC OXYGEN AND IN AN ALKALINE MEDIUM, AT A TEMPERATURE OF 15 TO 50JC, TO OBTAIN A COMPOUND OF FORMULA (I) IN WHICH R3 IS A GROUP OF FORMULA (A), R, R1 AND R2 ARE H OR ALKYL FROM C 1 TO 6, AND A IS A STRAIGHT-CHAIN ALKYLENE RADICAL. IT IS USED AS ANALGESIC AND/OR ANTIPYRETIC AGENTS. |