abstract |
PROCEDURE FOR PREPARING GUANIDINE DERIVATIVES. INCLUDES: REACTING A COMPOUND OF FORMULA (II), WHERE R14 IS ARYL AND R15 IS H, WITH AN AMINE OF FORMULA R1R2NH, TO OBTAIN THE COMPOUND OF FORMULA (I) WHERE R1 AND R2 ARE H, C 1 TO 10 OR OTHER ALKYL RADICALS IN THE RING X THE DOTTED LINE IS A DOUBLE BOND ON ONE SIDE OF THE N ATOM; Z IS C O N; A IS A PHENYL RADICAL, C 1 TO 7 CYCLOALKYLENE OR OTHERS; R3 IS FORMULA (III), WHERE R6 IS H, HYDROXY AND OTHERS; R7 IS H OR R6 AND R7 TOGETHER WITH N ARE A SATURATED RING OF 5, 6 OR 7 MEMBERS, OR OTHERS. THEY ARE LISTAMINE H-2 RECEPTOR ANTAGONISTS. |