abstract |
PROCEDURE TO PREPARE SUBSTITUTED PYRIDINE DERIVATIVES IN POSITIONS 2 AND 6. IT INCLUDES: A) TO CONTACT THE FORMULA (II) STARTING COMPOUND WITH A BOROHIDRIDE OF ALKALINE METAL, IN THE PRESENCE OF A FIRST SOLVENT TO DEVELOP A COMPOSITE OF A DIFFERENT COMPOSITE. FORMULA (III); AND B) PUT THE FORMULA COMPOUND (III) IN CONTACT WITH A NON-AQUEOUS BASE COMPOUND, OPTIONALLY IN THE PRESENCE OF A SECOND SOLVENT, TO FORM A SUBSTITUTED PIRIDINE DERIVATIVE IN POSITIONS 2 AND 6 OF FORMULA (I) WHERE R IS HERE LOWER, LOWER ALKYLENE AND OTHERS; R1 IS FLOWERED METHYL; R2 IS SELECTED FROM DIFLUOROMETILE, MONOFLUOROMETILE AND ALKYL RADICALS; Y X E Y ARE BOTH A GROUP ESTER. |