| abstract |
PROCEDURE FOR THE PREPARATION OF BENZAMIDE DERIVATIVES CONSISTS OF CONVERTING GROUP R5 FROM A COMPOUND OF FORMULA II INTO AN AMINO GROUP, BY MEANS OF ACID HYDROLYSIS WITH CLH, INTO AN INERT SOLVENT SUCH AS ETHANOL OR TETRAHYDROFURATURE AND AT TEMPERATURE AMPERATURE AND TEMPERATURE AMPERATURE OF REFLUX OF THE MIXTURE, TO OBTAIN A COMPOUND OF FORMULA I AND ITS SALTS OF ADDITION OF ACCEPTABLE PHARMACEUTICAL ACIDS. BEING; R1 HAL, CYANE OR TRIFLUOROMETHYL; R2 H AND R5, AN AMIDIC GROUP, ARE USED TO TREAT DEPRESSIVE STATES AND PARKINSONISM. |