http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-8505820-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd115dec46c157d3739020ebd4d866b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02 |
| filingDate | 1983-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1985-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-8505820-A1 |
| titleOfInvention | A PROCEDURE FOR PRODUCING A VACCINE THAT PREVENTS HEPATITIS B INFECTION |
| abstract | PROCEDURE TO PRODUCE A VACCINE THAT PREVENTS HEPATITIS B INFECTION, INCLUDING: A) HEATING AN AQUEOUS SOLUTION OF A FRACTION OF HUMAN PLASMA PROTEINS CONTAINING SURFACE ANTIGEN OF HEPATITIS B, AT A TEMPERATURE BETWEEN 50 AND 70 J BETWEEN 12 HOURS; B) SATURATE THE HEATED SOLUTION OF STAGE (A) WITH AMMONIUM SULPHATE, TO SEPARATE A FRACTION OF PRECIPITABLE PROTEINS AT 10-20 AND COLLECT A FRACTION OF PRECIPITABLE PROTEINS AT 40-50; C) CONTACT THE 40-58 SOLUTION WITH A COLLOIDAL SILICATE, TO OBTAIN ABSORBED HBSAG; D) ELUTE A PORTION OF ABSORBED HBSAG WITH A BUFFER SOLUTION AT PH BETWEEN 8.5 AND 9; E) NEUTRALIZE THE ELUATE OF STAGE (D); F) AN / ADD TO ELUATE, POLYETHYLENE GLYCOL UP TO A LEVEL OF 3 TO 7 (P / V) TO SEPARATE HEPATITIS B VIRUSES AND IMMUNOLOGICAL COMPLEXES; G) CONTINUE AN / ADDING POLYETHYLENE GLYCOL UNTIL A PRECIPITATE IS OBTAINED IN THE SUPERNATING LAYER OF (15-20) (P / V); H) FILTER THE PRECIPITATE TO RECOVER A FRACTION OF HBSAG; I) ULTRACENTRIFUGAR TO THE FRACTION OF THE STAGE (H); J) INACTIVATE THE FRACTION OF STAGE (I) WITH FORMALIN, AND K) REST ON THE RESULTING PRODUCT. |
| priorityDate | 1982-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.