abstract |
PROCEDURE FOR OBTAINING IMIDAZO 1,5-A PYRIDINES CONSISTS IN THAT IN A COMPOUND OF FORMULA (II) THE RING IS CLOSED TO GIVE A COMPOUND OF FORMULA (III), WHICH TRANSFORMS BL INTO B TO GIVE IMIDAZO 1,5 -A PYRIDINES OF FORMULA (I), WHERE R1 AND R2 ARE HO LOWER ALKYL; A IS ALKYLENE WITH C 1 TO 12, ALKYLENE OR ALKYLENE WITH C 2 TO 12; B IS CARBOXY, LOWER ALCOXY-CARBONYL AND OTHERS; RK2 AND RL2 ARE H OR LOWER ALKYL AND BL IS CARBOXI LOWER ALCOXY-CARBONYL, UNUSTITUTED CARBAMOYL AND OTHERS. IT IS CARRIED OUT IN THE PRESENCE OF A LEWIS ACID, AN INERT SOLVENT SUCH AS TOLUENE AND AT TEMPERATURES BETWEEN 25 AND 150JC, THEY HAVE APPLICATION AS INHIBITORS OF TROMBOXAN-SYNTHETASE. |