abstract |
PROCEDURE FOR OBTAINING DERIVATIVES FROM CEPHALOSPORINS AND THEIR SALTS WITH PHYSIOLOGICALLY COMPATIBLE ACIDS, OF FORMULA (I), IN WHICH IT IS NOT VALUE 0 OR 1 YA, B, X, R1 AND R2 MAY BE SEVERAL RADIALS, CONSISTING IN ACILATION OF THE COMPOUND OF FORMULA (II) WITH THE ACID OF FORMULA (III), FOLLOWED BY THE TREATMENT WITH AN ACID OF FORMULA B- (CH2) N-COOH OR A THIOACIDE OF FORMULA B- (CH2) N-COSH; AND, FINALLY, ELIMINATION OF THE PROTECTIVE GROUPS OF THE AMIN AND CARBOXI FUNCTIONS; FORMULAS IN WHICH TR IS TRITILO, TBU IS TERBUTILO AND THE OTHER SYMBOLS ARE THE SAME AS IN FORMULA (I). THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS AS ANTIBIOTICS. |