abstract |
PROCEDURE FOR PREPARING DERIVATIVES OF PHENYL CYLOBUTANE, CONSISTING OF UNDERGOING A REDUCING AMINATION REACTION TO A KETONE OF FORMULA (II), MIXING THE KETONE WITH AN AMINE OF FORMULA R3R4NH, IN THE PRESENCE OF A REDUCING AGENT, SUCH AS FORMULA SODIUM OR ACIANOBHINE SODIUM INERT SOLVENT AT TEMPERATURE INCLUDED BETWEEN 0J AND THE BOILING POINT OF THE SOLVENT, TO OBTAIN PENYL CYLOBUTANE DERIVATIVES OF FORMULA (I), WHERE R1 IS AN ALCOHYL GROUP WITH C 1 TO 6, CYCLOALCOHYL AND OTHERS; R2 IS H OR AN ALCOHYL GROUP WITH C 1 TO 3; R3 AND R4 ARE H STRAIGHT OR BRANCHED CHAIN ALCOHYL GROUP WITH C 1 TO 4 AND OTHERS; R5 AND R6 ARE H, HALO, TRIFLUOROMETHYL AND OTHERS. IT HAS THERAPEUTIC APPLICATION FOR POSSESSING ANTI-DEPRESSIVE ACTIVITY. |