abstract |
PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINS, IN GENERAL FORMULA (I), IN WHICH THE COOA ACID GROUP IS FOUND IN ACID FORM, IN THE FORM OF SALT OR IN THE FORM OF HYDROLYLABLE ESTER; R1 REPRESENTS A RADICAL; R2 AND R3 REPRESENT, INDEPENDENTLY, HYDROGEN, AN ALKYL GROUP OR A LOWER ALKYNILE GROUP; R4 AND R5 REPRESENT, INDEPENDENTLY, HYDROGEN, A LOWER RENT GROUP OR A LOWER ALKENYL GROUP; YX DESIGNATES THE ANION OF AN ACID. IT CONSISTS IN REACTION AMINO-7-BROMINE-ETHYL-3-C EPEMO-3-CARBOXYLATE OF TERCIBUTIL-4 S-OXIDE, WITH A FORMULA (II) ACID, IN THE QUETR IS A PROTECTOR GROUP OF THE AMINO GROUP; AND R1 IS A LABIL ESTER OF RADICAL R1 WHOSE ACID FUNCTION HAS BEEN ACTIVATED, IN A SUITABLE SOLVENT, SUCH AS METHYLFORMAMIDE. THE PRODUCT OBTAINED IS REACTED WITH A THIOUREA OF GENERAL FORMULA (III). OF APPLICATION AS ANTIBIOTICS IN HUMAN OR VETERINARY MEDICINE. |