abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF PHENYLTIADIAZINONE, OF FORMULA (I), IN WHICH X IS -CRR-, WHERE R AND R ARE HYDROGEN OR C1-4 ALKYL; AND IT IS SULFUR; YR, R, R AND R MAY BE SEVERAL TYPES OF RADICALS, CONSISTING OF THE REACTION OF A PHENACIL HALIDE OF FORMULA (II) WITH A THIOCARBAZATE OF FORMULAS H2NNHSCOR OR H2NNHCSO-MB, IN WHICH HAL IS A HALOGEN ATOM, R C1-4, MB IS AN ALKALINE METAL OR AMMONIUM ION, AND THE OTHER SYMBOLS HAVE THE SAME MEANING AS IN FORMULA (I). THE REACTION IS EFFECTED IN AN ORGANIC SOLVENT OR DILUENT, AT REFLUX TEMPERATURE. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR CARDIOTONIC AND / OR ANTI-HYPERTENSIVE PROPERTIES. |