abstract |
PROCEDURE FOR THE PREPARATION OF CARBACICLINE DERIVATIVES.CONSISTED IN: A) THE REACTION OF A COMPOUND OF FORMULA (II) WITH A REAGENT OF WITTING OF FORMULA (III), OR B) THE ETERIFICATION IN THE PRESENCE OF A BASE OF A FORMULA COMPOUND ( IV) WITH A HALOGENOACETIC ACID DERIVATIVE OF FORMULA (V), TO OBTAIN A COMPOUND OF FORMULA (I). THE RADICALS HAVE THE FOLLOWING MEANING: R1, ES -CH2OH OR AA4-COBOR2 OR -ILCO-NHR3; R2 IS HYDROGEN WITH A RADICAL ALCOHYL, CYCLOALCOHYL OR ARYL; R3 IS A RADICAL ALCANOYL OR ALCANSULFONIL; X IS OXYGEN OR A GROUP-CH2; A IS A TRANS-CHFCH OR -CFC GROUP; W IS A HYDROXYMETHYLENE GROUP; D, IS A STRAIGHT CHAIN ALCOHYLENE GROUP WITH C 1 TO 5; E, REPRESENTS A LINK -CFC-; B IS A DOUBLE LINK OR A GROUP -CHFCBR-; R4 IS A GROUP ALCOHIL, CYCLOALCOHYL OR ARYL; R5, IT IS A HYDROXY GROUP; N MAY BE 1, 2 OR 3; AND M, 1 OR 2. OF PHARMACOLOGICAL APPLICATION FOR ITS HYPOTENSIVE AND BRONCODILATOR EFFECTS. |