abstract |
PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINS, OF GENERAL FORMULA (I), IN WHICH A MEANS A PHENYL, 4-HYDROXIPHENYL OR 3-THENYL GROUP; D MEANS GROUP 1-VINYL-TETRAZOLE-5-ILO OR 1-ALILTETRAZOLE-5-ILO; R MEANS A GROUP OF GENERAL FORMULA: NHR, WHERE R MEANS A GROUP 3-PIRIDYL, 5-PIRIMIDINYL OR 2-THENYL; AND E MEANS AN EASILY SEPARABLE HYDROGEN ATOME OR CARBOXYL PROTECTIVE GROUP ~ AIN VITRO ~ B OR ~ AIN LIVE ~ B, AND ITS PHYSIOLOGICALLY COMPATIBLE SALTS WITH INORGANIC OR ORGANIC BASES. IT CONSISTS IN REACTION A DERIVATIVE OF CEPHALOSPORANIC ACID, OF GENERAL FORMULA (II), IN WHICH AYD HAVE THE SIGNIFICANCES ALREADY INDICATED, WITH A DERIVATIVE OF PIRIMIDINE, OF GENERAL FORMULA (III), IN WHICH R HAS THE SIGNIFICANCE AND ALREADY INDICATED, AND B IS THE GROUP -NCO. APPLICATION IN PROPHYLAXIS AND IN LOCAL INFECTION CHEMOTHERAPY. |