abstract |
PROCEDURE FOR OBTAINING PEPTIDES AND THEIR PHYSIOLOGICALLY COMPATIBLE SALTS, OF FORMULA (I), IN WHICH R, R, R, R AND R MAY BE SEVERAL TYPES OF RADICALS. IT CONSISTS OF THE REACTION OF A COMPOUND OF FORMULA (II), OR A SALT OF THE SAME, WITH A COMPOUND OF FORMULA (III) OR A SALT OF THE SAME, IN WHICH R <A IS ALCANOYL OR ARALKANOYL; R <A IS PROTECTED CARBOXI; R <A IS AMINO PROTECTOR GROUP; AND R 3 AND R HAVE THE SAME MEANING AS IN FORMULA (I); FOLLOWED BY THE ELIMINATION REACTION OF THE PROTECTIVE GROUPS. THE FORMATION REACTION OF THE PEPTIDIC BOND IS EFFECTED IN AN INERT SOLVENT, IN THE PRESENCE OF A CONDENSING AGENT, UNDER ANHYDROUS CONDITIONS, AT A TEMPERATURE -20 C AND THE AMBIENT. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR ANTITUMORAL ACTIVITY AND AS INTERMEDIATES FOR THE SYNTHESIS OF OTHER COMPOUNDS WITH BIOLOGICAL ACTIVITY. |