| abstract |
PROCEDURE FOR THE OBTAINING OF COMPOUNDS OF 2-ACILAMINOMETIL-1H-2,3-DIHIDRO-1,4-BENZODIAZEPINA AND ITS OPTICAL ISOMERS AND ADDITIONAL SALTS OF ACID, IN WHICH R -R MAY BE VARIOUS TYPES OF RADICALS; Y N VALE 0-2. CONSISTS OF THE REACTION OF ACILATION OF COMPOUNDS OF 2-AMINOMETIL-1H-2,3-DIHIDRO-1,4-BENZODIAZEPINA, OF FORMULA (II), WITH ACIDS OR ACID DERIVATIVES, OF FORMULA R - (CH) <N- CO-Y, IN WHICH Y IS HYDROXY OR A SEPARABLE GROUP BY AMINOLYSIS AND THE OTHER SYMBOLS HAVE THE SAME MEANING AS IN FORMULA (I). THE REACTION IS EFFECTED IN AN INERT SOLVENT AT TEMPERATURES BETWEEN -30 C AND THE BOILING OF THE SOLVENT. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR ANTICONVULSIVE EFFECT. |