| abstract |
PROCEDURE FOR OBTAINING CYCLOHEPTENE DERIVATIVES, 1- 2- (4,5,10,11-TETRAHIDRO-1H-DIBENZO A, D CYCLOHEPTEN-5-IL) ETHYL PYRROLIDINE AND ITS PHYSIOLOGICALLY COMPATIBLE ACID ADDITION SALTS. IT CONSISTS OF THE REDUCTION OF 1- 2- (10,11-DIHYDRO-5H-DIBENZO A, D CYCLOHEPTEN-5-IL) ETHYL PYRROLIDINE, FOLLOWED BY ISOLATION OF THE PRODUCT FORMED AS A FREE BASE OR AS SALT. THE REDUCTION IS CARRIED OUT WITH AN ALKALINE METAL, IN A SOLVENT SUCH AS LIQUID AMMONIA OR AN AMINE, IN THE PRESENCE OF A PROTON DONOR, AT A TEMPERATURE OF BETWEEN -50 C AND THE BOILING TEMPERATURE OF THE MIXTURE. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THE CONTROL AND PREVENTION OF ALLERGIC REACTIONS, SUCH AS URTICARIA, HAY FEVER, ANAPHYLAXIS AND HYPERSENSITIVITY TO MEDICINES. |