abstract |
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2,4-DIAMINOQUINAZOLINE, OF GENERAL FORMULA (I), WHERE AND IS HYDROGEN OR CHLORINE; AND IS OR; AND IT IS HYDROGEN OR OR; R AND R 2 MAY BE THE SAME OR DIFFERENT AND MEAN HYDROGEN, ALKYL OF 1 TO 5 CARBON ATOMS, CYCLOALKYL OF 3 TO 8 CARBON ATOMS, OR HYDROXIALKYL OF 2 TO 5 CARBON ATOMS; AND R IS THE RENT OF 1 TO 3 CARBON ATOMS, AND ITS PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS. IT CONSISTS OF REACTING A COMPOUND OF FORMULA (II), WITH A COMPOUND OF FORMULA A NR R, WHERE Y, Y, Y, R AND R HAVE THE MEANINGS ALREADY INDICATED; Q IS CN; Y A IS C (= NH) XR OR C (= NH) NH, WHERE X IS O O S, AND R IS ALKYL OF 1 TO 6 CARBON ATOMS. FOR APPLICATION IN PHARMACEUTICAL PREPARATIONS AS ANTIHYPERTENSIVE AGENTS. |