abstract |
PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 6 <007> -METILHIDROCORTISONA, OF FORMULA (I), IN WHICH R IS AN OXOALCOHILO C <003> OR A BENZOIL; Y R IS 1-OXOALCOHILO C <003>. CONSISTS IN THE REACTION OF ESTERIFICATION OF A 6 <007> -METILHIDROCORTISON-17-ACILATO DE FORMULA (II), IN WHICH R IS THE SAME AS IN FORMULA (I), IN POSITION 21, WITH AN ALCANCARBOXILICO A < 003>, OR A REACTIVE DERIVATIVE OF THE SAME; ACYLLATION OF POSITION 17 WITH A CARBOXYL ACID CHLORIDE OR ANHYDRIDE, IN THE PRESENCE OF 4-DIMETHYLAMINOPYRIDINE; AND, FINALLY, SEPARATION FROM THE PROTECTIVE GROUP. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THE TREATMENT, BY LOCAL ROUTE, OF SKIN DISEASES. |