| abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF ISOQUINOLEIN AND ITS SALTS WITH PHYSIOLOGICALLY COMPATIBLE ACIDS, OF FORMULA (I), IN WHICH M AND N ARE VALUE 1 OR 2, R2 IS HYDROGEN OR C1-6 ALOHYL AND R1 AND R3 MAY BE VARIOUS RADICAL. CONSISTS OF THE REACTION OF A COMPOUND OF FORMULA (II) WITH TWO EQUIVALENTS OF AT LEAST ONE AMINE OF FORMULA (III), IN WHICH Y IS HALOGEN, ALCOHYLOXY OR ALCOHILTIO C1-4, AND THE OTHER SYMBOLS HAVE THE SAME MEANING IN THE FORMULA (I). THE REACTION IS CARRIED OUT IN AN INERT SOLVENT OR IN A LIQUID MINE THAT ALSO ACTS AS AN ACCEPTOR, AT A TEMPERATURE BETWEEN 80 AND 220C. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS DUE TO THEIR EFFECTS ON THE CENTRAL NERVOUS SYSTEM AND ON THE CARDIAC CIRCULATORY SYSTEM. |