abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF 7-OXO-1-AZABICYCLO ACID (3.2.0) HEPT-2-EN-2-CARBOXYL AND ITS PHYSIOLOGICALLY COMPATIBLE SALTS, OF FORMULA (I), IN WHICH A IS A HYDROCARBIL RADICAL ALIPHATIC SATURATED, VERSATILE; "P" IS VALUE 1 OR 2, R3 IS A PROTECTED CARBOXI OR CARBOXI AND R1, R2 AND X CAN BE SEVERAL TYPES OF RADICALS. IT CONSISTS OF THE RING CLOSURE REACTION, BY HEATING TO A TEMPERATURE BETWEEN 30 AND 200 DEGREES CENTIGRADE, OF A PHOSPHORUS-ILIDE-DERIVED, OF FORMULA (II), WHERE R5 IS ALKYL OR ARYL, R''3 IS A PROTECTED CARBOXI GROUP, R''1 AND R''2 CAN BE SEVERAL TYPES OF RADICALS YX, A AND "P" HAVE THE SAME MEANING AS IN FORMULA (I). THE REACTION IS CARRIED OUT IN AN INERT ORGANIC SOLVENT AND UNDER INERT ATMOSPHERE. |