abstract |
PROCEDURE FOR OBTAINING CEFEM COMPOUNDS AND ITS PHYSIOLOGICALLY COMPATIBLE SALTS OF FORMULA (I), IN WHICH R1 IS A SUBSTITUTED AMINO-HETEROCYCLIC RADICAL, R2 IS PROTECTED CARBOXI OR CARBOXY AND IS WITHOUT A LOWER SUBSTITUTE ALCOHYLENE OR SUBSTITUTE ALCOHYLENE. IT CONSISTS FUNDAMENTALLY OF THE AMIDIFICATION REACTION OF THE FORMULA COMPOUND (II), OR A REACTIVE DERIVATIVE OR A SALT OF THE SAME, WITH THE FORMULA COMPOUND R1-A-COOH, IN WHICH R1, R2 ALREADY HAVE THE SAME MEANINGS AS IN THE FORMULA (I). THE REACTION IS CARRIED OUT IN AN INERT SOLVENT AND IN THE PRESENCE OF A CONDENSING AGENT. IF REAGENTS ARE USED WITH PROTECTED FUNCTIONAL GROUPS, THE PROTECTIVE GROUPS MAY BE SEPARATED LATER BY CONVENTIONAL METHODS. |