| abstract |
PROCEDURE FOR THE PREPARATION OF 5-SULFAMOYLORTANILIC ACIDS OF FOMULA (I), IN WHICH R IS ALCOHYL, ALKENYL, CYCLOALKYL OR CYCLOALKYLALKYL, AND AR PHENYL, THENYL OR FUNYL. IT IS BASED ON THE SAPONIFICATION OF AN ESTER OF FORMULA (II), Z BEING AN AROMATIVE RADICAL, IN AN AQUEOUS ENVIRONMENT, WITH AN INORGANIC BASE LIKE SOSA OR POTASE LEGACY. THE SAPONIFICATION SOLUTION IS NEUTRALIZED, AT ROOM TEMPERATURE, WITH A MINERAL OR ORGANIC ACID. THE CRYSTALIZED PRODUCT, IN THE FORM OF SODIUM OR POTASSIUM SALTS, IS COLLECTED BY PRECIPITATION. IT IS WASHED WITH AN ORGANIC SOLVENT AND RECYSTALIZED IN AQUEOUS ALCOHOLS. THEY ARE USED IN PHARMACEUTICAL PREPARATIONS AS SALIDIURETIC AGENTS. |