| abstract |
PROCEDURE TO OBTAIN BENZODIAZEPINES, OF STRUCTURAL FORMULA (I), WHERE R1, R2 AND R3, INDEPENDENTLY ARE HYDROGEN, HALOGEN, TRIFLUORMETHYL OR NITRO; N IS 1,2 OR 3, AND PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS. IT CONSISTS IN REACTING A COMPOUND OF STRUCTURAL FORMULA (II), WHERE R1, R2 AND R3 HAVE THE MEANINGS ALREADY INDICATED, IN THE PRESENCE OF TETRAHYDROFURAN AND AT REFLUX TEMPERATURE, WITH AN ISOTHIOCYANATE X-CH2)N-1NCS, WHERE N HAS THE MEANING ALREADY INDICATED, AND X IS HALOGEN. PHARMACEUTICALLY ACCEPTABLE, NON-TOXIC ADDITION SALTS ARE PREPARED BY TREATING THE COMPOUNDS OF FORMULA (I) WITH ORGANIC OR INORGANIC ACIDS. |