| abstract |
PROCEDURE FOR OBTAINING 2-HALOPYRIDINES, ITS SALTS, ADDITION COMPOUNDS AND PRECURSORS, FROM FORMULA (I), IN WHICH X IS CHLORINE OR BROMINE, AND AR IS PHENYL OR A SUBSTITUTED PHENYL. IT CONSISTS OF THE AROMATIC NUCLEOFILA SUBSTITUTION REACTION OF AN AROMATIC COMPOUND ARH WITH AN ACIL HALIDE OF FORMULA (II), IN WHICH AR AND X HAVE THE SAME MEANING AS IN FORMULA (I), E AND IS A HALOGEN, PARTICULAR. THE REACTION IS CARRIED OUT UNDER FRIEDEL-CRAFST CONVENTIONAL CONDITIONS, ADJUSTING THE SAME ACCORDING TO THE AROMATIC COMPOUND USED. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THEIR ACTIVITIES ANALGESIC, ANTI-INFLAMMAR, ANTIPIRETICAS AND AS A SEDANT |