abstract |
PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-HYDROXYTETHYDROPYRAN 2-ONA. REFERS TO THE PREPARATION OF STRUCTURE COMPOUNDS (I), WHERE A IS HYDROGEN OR METHYL, E IS A TYPE (II) OR (III) LINK, R1 IS LOCATED IN ORTHO POSITION WITH RESPECT TO THE RADICAL E AND IS HALOPHENYLOXY, HALOPHENIALCOPHENIAL , ESPECIALLY WHERE HALO IS FLUORINE OR CHLORINE; R2 AND R3 ARE HALO, ESPECIALLY CHLORINE, IN POSITIONS 4 AND 6. ALSO REFERS TO THE HYDROXIACIDES RESULTING FROM THE HYDROLYTIC OPENING OF THE LACTONE RING, THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE HYDROXIACIDES AND THE INFLIMERIC DILYLSTERYLSTERYL FYDROXYLS. FOR ITS PREPARATION, THE DIANION OF AN ACETOACETIC ESTER IS REACTED WITH AN ALDEHYDE OF STRUCTURE (IV). THE 3-CETO GROUP IS REDUCED TO THE HYDROXYL GROUP. ESTER IS SAPONIFIED AND CARBOXYL IS LACTONIZED WITH 6-HYDROXYL. THEY ARE USED AS INHIBITORS OF THE SYNTHESIS OF CHOLESTEROL. *FORMULA* |