| abstract |
PROCEDURE FOR THE PREPARATION OF PHTHALAZINE, OF GENERAL FORMULA (I), OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT, WHERE R'' IS AN ALKYL GROUP; Y IS A GROUP OF THE FORMULA -(CH2)M-Z; Z BEING DIFFERENT TYPES OF RADICALS; M IS 1 OR 2. IT CONSISTS IN REACTING A PHTHALAZINE OF FORMULA (III), WITH AN AMINE OF FORMULA (IV), OPTIONALLY FOLLOWED BY REACTING THE PRODUCT SO OBTAINED WITH A NON-TOXIC ACID TO FORM A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT . Q'' IS A CHLORINE, BROMINE, IODINE, LOWER ALCOXY OR TIO GROUP. THIS COMPOUND HAS APPLICATION IN THE TREATMENT OF HEART RHYTHM. *FORMULA* |