abstract |
PROCEDURE FOR OBTAINING DERIVATIVES OF 1-PHENYL-3(4-PIPERIDIL)-1-PROPANONE, OF FORMULA (I), USEFUL AS ANTIARRYTHMICS, ANTIDEPRESSANTS AND ANXIOLITICS, IN WHICH X AND Y ARE EACH HYDROGEN OR ONE OF SEVERAL TYPES OF RADICALS AND A IS A >C=O, CHOH OR CH2 RADICAL, OR A SALT OF SAID COMPOUND, WITH A PHARMACOLOGICALLY ACCEPTABLE ACID. IN THE PRESENCE OF A FRIEDEL AND CRAFTS CATALYST, A BENZENE DERIVATIVE WITH SUBSTITUENTS X AND Y OF THE SAME MEANING AS IN FORMULA (I) IS REACTED WITH A PIPERIDINE DERIVATIVE OF FORMULA (II), IN WHICH Z'' IS A GROUP OH OR A HALOGEN ATOM. THE COMPOUND OBTAINED IS HYDROLYZED TO THE DERIVATIVE OF FORMULA (I). IF YOU WANT THE RADICAL A IN THIS TO BE CHOH OR CH2, THE RESULTING PRODUCT IS REDUCED WITH HYDRAZINE IN THE PRESENCE OF SODIUM HYDROXIDE IN ALCOHOL AT BOILING TEMPERATURE OR BY CATALYTIC HYDROGENATION. *FORMULA* |