abstract |
PROCEDURE FOR OBTAINING VINYL-3 CEPHALOSPORIN DERIVATIVES, WHICH RESPOND TO FORMULAS (I) AND (II), AND THEIR SALTS, WHERE R1, R3, R4, R, R1 RAISED O AND R2 RAISED O ARE VARIOUS TYPES OF RADICALS, AND R2 IS EASILY REMOVABLE BY ENZYMATIC VIA. ACCORDING TO THE RELATIVE VALUES OF THE RADICALS INDICATED, THE PRODUCTS WITH GENERAL FORMULA (I) ARE OBTAINED BY DIFFERENT PROCEDURES. ONE OF THEM CONSISTS OF THE REACTION OF A PRODUCT OF FORMULA (III) ON A DERIVATIVE OF CEPHALOSPORIN, OF GENERAL FORMULA (IV), WHICH IS IN THE FORM OF METHYL-3 BICICLOOCTERNO-2 OR -3 METHYLENE-3 BICICLOOCTENO, BEING R ''11 AND R11 DIFFERENT RADICALS. A PROCEDURE FOR OBTAINING A DERIVATIVE (V) OF TYPE (II) CONSISTS IN PREPARING A COMPOUND BY HYDROLYSIS IN AN ACID MEDIUM FROM THE ENAMINE OR FROM A MIXTURE OF ITS ISOMERS. THESE COMPOUNDS HAVE ANTIBACTERIAL PROPERTIES. *FORMULA* |